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ATSAMD21E16
  • ATSAMD21E16
  • ATSAMD21E16
  • ATSAMD21E16
  • ATSAMD21E16
  • ATSAMD21E16

ATSAMD21E16

In Production

NOTE: ATSAMD21E16A is not recommended for new designs, please use ATSAMD21E16B.A low-power, high-performance ARM® Cortex®-M0+ -based Flash microcontroller optimized for control applications, the ATSAMD21E16 is ideal for a wide range of home automation, consumer, metering, and industrial applications. It features:64KB of Flash and 8KB of SRAMUp to 48MHz operating frequencyFive serial communication (SERCOM) modules configurable as UART/USART, SPI or I2C, four 16-bit timer/counters, two 24-bit timer/counters, 32-bit Real-Time Clock and calendar, one 14-channel 12-bit ADC, one 10-bit DAC and four analog comparators1.62V to 3.63V power supply32-pin package with up to 26 GPIO pinsSupported by MPLAB X IDE and MPLAB Harmony.Functional SafetyThis device supports the ISO 26262 (ASIL B...

Microchip Technology ATSAMD21E16 Product Info

16 April 2026 0

Parameters

Part Family

SAMD21

CPU Type

Cortex-M0+

MaxSpeed (MHz)

48

Program Memory Size (KB)

64

SRAM (KB)

8

Temp. Range Min.

-40

Temp. Range Max.

125

Operation Voltage Min.(V)

1.62

Operation Voltage Max.(V)

3.63

SPI

4

I2C

4

UART

4

QSPI

0

Crypto Engine

No

Internal Oscillator

32khz, 32Khz ULP, 8Mhz

Pin Count

32

Features

  • Single-cycle hardware multiplierMicro Trace Buffer64KB in-system self-programmable Flash8KB SRAM MemoryPower-on reset (POR) and brown-out detection (BOD)Internal and external clock options with 48MHDigital Frequency Locked Loop (DFLL48M) and 48MHto 96MHFractionalExternal Interrupt Controller (EIC)16 external interruptsOne non-maskable interruptTwo-pin Serial Wire Debug (SWD) programming, test and debugging interfaceDrop in compatible with SAM D20Idle and standby sleep modesSleepWalking peripherals12-channel Direct Memory Access Controller (DMAC)12-channel Event SystemOne 16-bit TC with compare/capture channelsOne 8-bit TC with compare/capture channelsOne 32-bit TC with compare/capture channels, by using two TCsUp to four compare channels with optional complementary outputGeneration of synchronized pulse width modulation (PWM) pattern across port pinsDeterministic fault protection, fast decay and configurable dead-time between complementary outputDithering that increase resolution with up to 5 bit and reduce quantization error32-bit Real Time Counter (RTC) with clock/calendar functionWatchdog Timer (WDT)CRC-32 generatorEmbedded device functionEight endpointsUSART with full-duplex and single-wire half-duplex configurationI2C Bus up to 3.4MHzSMBUS/PMBUSSPILIN slaveDifferential and single-ended input1/2x to 16x programmable gain stageAutomatic offset and gain error compensationOversampling and decimation in hardware to support 13-, 14-, 15- or 16-bit resolution10-bit, 350ksps Digital-to-Analog Converter (DAC)Two Analog Comparators (AC) with window compare function256-channel capacitive touch and proximity sensing26 GPIO pins32-pin TQSP, QFN, WLCSP1.62V – 3.63V
    • Memories
    • Micro Trace Buffer
    • 64KB in-system self-programmable Flash
    • 8KB SRAM Memory
    • Power-on reset (POR) and brown-out detection (BOD)
    • Internal and external clock options with 48MHDigital Frequency Locked Loop (DFLL48M) and 48MHto 96MHFractional
    • External Interrupt Controller (EIC)
    • 16 external interrupts
    • One non-maskable interrupt
    • Two-pin Serial Wire Debug (SWD) programming, test and debugging interface
    • Drop in compatible with SAM D20
    • Idle and standby sleep modes
    • SleepWalking peripherals
    • 12-channel Direct Memory Access Controller (DMAC)
    • 12-channel Event System
    • One 16-bit TC with compare/capture channels
    • One 8-bit TC with compare/capture channels
    • One 32-bit TC with compare/capture channels, by using two TCs
    • Up to four compare channels with optional complementary output
    • Generation of synchronized pulse width modulation (PWM) pattern across port pins
    • Deterministic fault protection, fast decay and configurable dead-time between complementary output
    • Dithering that increase resolution with up to 5 bit and reduce quantization error
    • 32-bit Real Time Counter (RTC) with clock/calendar function
    • Watchdog Timer (WDT)
    • CRC-32 generator
    • Embedded device function
    • Eight endpoints
    • USART with full-duplex and single-wire half-duplex configuration
    • I2C Bus up to 3.4MHz
    • SMBUS/PMBUS
    • SPI
    • LIN client
    • Differential and single-ended input
    • 1/2x to 16x programmable gain stage
    • Automatic offset and gain error compensation
    • Oversampling and decimation in hardware to support 13-, 14-, 15- or 16-bit resolution
    • 10-bit, 350ksps Digital-to-Analog Converter (DAC)
    • Two Analog Comparators (AC) with window compare function
    • 256-channel capacitive touch and proximity sensing
    • 26 GPIO pins
    • 32-pin TQSP, QFN, WLCSP
    • 1.62V – 3.63V
      Memories
      Processor
    • Arm Cortex-M0+ CPU running at up to 48MHz

    Description

    NOTE: ATSAMD21E16A is not recommended for new designs, please use ATSAMD21E16B.

    A low-power, high-performance ARM® Cortex®-M0+ -based Flash microcontroller optimized for control applications, the ATSAMD21E16 is ideal for a wide range of home automation, consumer, metering, and industrial applications. It features:

    • 64KB of Flash and 8KB of SRAM
    • Up to 48MHz operating frequency
    • Five serial communication (SERCOM) modules configurable as UART/USART, SPI or I2C, four 16-bit timer/counters, two 24-bit timer/counters, 32-bit Real-Time Clock and calendar, one 14-channel 12-bit ADC, one 10-bit DAC and four analog comparators
    • 1.62V to 3.63V power supply
    • 32-pin package with up to 26 GPIO pins


    Supported by MPLAB X IDE and MPLAB Harmony.

    Functional Safety

    This device supports the ISO 26262 (ASIL B), IEC 61508 (SIL 2) and IEC 60730 (Class B) functional safety standards.  

    ·   The Functional Safety Manual, FMEDA and information on the Diagnostic Software are available under NDA through the request form on the 32-bit Microcontrollers Functional Safety web page.

    ·   To request any information about the SIL 2 STL, please fill out and submit the request form on Industrial Safety Self-Test Library web page.

    ·  Learn more about  32-bit MCUs with Functional Safety capabilities including device hardware and certified software libraries. 

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